Total body Na content is increased secondary to activation of the renin angiotensin aldosterone system (RAAS) and increased Na avidity in the kidney. Increased total body water primarily accumulates in extracellular spaces, the bulk of which is interstitial with a lesser amount as plasma volume.
BOX AND WHISKER PLOT IN EXCEL FOR MAC 15.3 SERIES
Quantification of diuretic responsiveness in the clinical setting opens new diagnostic, treatment, and monitoring strategies.Ĭongestive heart failure (CHF) stems from a series of hemodynamic, neurohormonal, and cardiorenal responses that promote retention of water and sodium (Na) in dogs and humans. Differentiation of dogs fulfilling predefined criteria for LDR was examined using receiver operating characteristic (ROC) curves.ResultsPredicted uNa output at 180 minutes (rs = 0.763,, 0.375-0.923], P = .002) and 270 minutes (r = 0.816,, P Conclusions and clinical importanceUrinary Na excretion and uVol are complementary but distinct aspects of diuretic responsiveness in dogs. Spot urine samples at 180 and 270 minutes after furosemide (3 mg/kg PO) were used to predict cumulative uVol and uNa output over 7 hours.
BackgroundIn human patients, cumulative urine volume (uVol) and urine sodium (uNa) can be predicted using spot urine samples and these quantitative measures help detect low diuretic responsiveness (LDR).Hypothesis/objectivesFormulas using spot urine samples predict cumulative uVol and uNa output after oral administration of furosemide to dogs.AnimalsEight healthy dogs, 6 dogs with congestive heart failure (CHF).MethodsProspective interventional study.
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